Mechanism of Spinal Transmission in Tactile Allodynia
نویسندگان
چکیده
منابع مشابه
Intrathecal delivery of PDGF produces tactile allodynia through its receptors in spinal microglia
Neuropathic pain is a debilitating pain condition that occurs after nerve damage. Such pain is considered to be a reflection of the aberrant excitability of dorsal horn neurons. Emerging lines of evidence indicate that spinal microglia play a crucial role in neuronal excitability and the pathogenesis of neuropathic pain, but the mechanisms underlying neuron-microglia communications in the dorsa...
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OBJECTIVE Diabetic neuropathy is manifested either by loss of nociception (painless syndrome) or by mechanical hyperalgesia and tactile allodynia (pain in response to nonpainful stimuli). While therapies with vasodilators or neurotrophins reverse some functional and metabolic abnormalities in diabetic nerves, they only partially ameliorate neuropathic pain. The reported link between nociception...
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15 صفحه اولCutaneous tactile allodynia associated with microvascular dysfunction in muscle
BACKGROUND Cutaneous tactile allodynia, or painful hypersensitivity to mechanical stimulation of the skin, is typically associated with neuropathic pain, although also present in chronic pain patients who do not have evidence of nerve injury. We examine whether deep tissue microvascular dysfunction, a feature common in chronic non-neuropathic pain, contributes to allodynia. RESULTS Persistent...
متن کاملNeurobiology of Disease Spinal Dorsal Horn Calcium Channel 2 -1 Subunit Upregulation Contributes to Peripheral Nerve Injury- Induced Tactile Allodynia
Peripheral nerve injury induces upregulation of the calcium channel 2 -1 structural subunit in dorsal root ganglia (DRG) and dorsal spinal cord of spinal nerve-ligated rats with neuropathic pain, suggesting a role of the calcium channel 2 -1 subunit in central sensitization. To investigate whether spinal dorsal horn 2 -1 subunit upregulation derives from increased DRG 2 -1 subunit and plays a c...
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ژورنال
عنوان ژورنال: The Journal of the Kyushu Dental Society
سال: 1998
ISSN: 0368-6833,1880-8719
DOI: 10.2504/kds.52.258